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Publications

Zedler BK, Joyce A, Murrelle L, Kakad P, Harpe SE. A pharmacoepidemiologic analysis of the impact of calendar packaging on adherence to self-administered medications for long-term use. Clin Ther. 33(5): 581-97, 2011. PMID: 21665043

Zedler BK, Kakad P, Colilla S, Murrelle L, Shah NR. Does packaging with a calendar feature improve adherence to self-administered medication for long-term use? A systematic review. Clin Ther. 33(1): 62-73, 2011. PMID: 21397775

Maher BS, Vladimirov VI, Latendresse SJ, Thiselton DL, McNamee R, Kang M, Bigdeli TB, Chen X, Riley BP, Hettema JM, Chilcoat H, Heidbreder C, Muglia P, Murrelle EL, Dick DM, Aliev F, Agrawal A, Edenberg HJ, Kramer J, Nurnberger J, Tischfield JA, Devlin B, Ferrell RE, Kirillova GP, Tarter RE, Kendler KS, Vanyukov MM. The AVPR1A Gene and Substance Use Disorders: Association, Replication, and Functional Evidence. Biol Psychiatry, 2011. PMID: 21514569

Applebee MK, Joyce AR, Conrad TM, Pettigrew DW, Palsson BØ. Functional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli. J Biol Chem. 286(26):23150-9, 2011. PMID: 21550976

Edmiston JS, Archer KJ, Scian MJ, Joyce AR, Zedler BK, Murrelle EL. Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. Biomarkers. 15(8):715-30, 2010. PMID: 20887155

Rana GS, York TP, Edmiston JS, Zedler BK, Pounds JG, Adkins JN, Varnum SM, Smith RD, Liu Z, Li G, Webb BT, Murrelle EL, Flora JW. Proteomic biomarkers in plasma that differentiate rapid and slow decline in lung function in adult cigarette smokers with chronic obstructive pulmonary disease (COPD). Anal Bioanal Chem. 397(5):1809-19, 2010. PMID: 20442989

York TP, van den Oord EJCG, Langston TB, McKinney WJ, Webb BT, Murrelle EL, Zedler BK, Edmiston JS, Flora JW: High-resolution mass spectrometry proteomics for the identification of candidate plasma protein biomarkers for chronic obstructive pulmonary disease. Biomarkers, 15(4):367-77, 2010. PMID: 20429838

Meng H, Joyce AR, Adkins DE, Basu P, Jia Y, Li G, Sengupta TK, Zedler BK, Murrelle EL, van den Oord EJCG: A statistical method for excluding non-variable CpG sites in high-throughput DNA methylation profiling. BMC Bioinformatics 11:227, 2010. PMID: 20441598

McClay JL, Adkins DE, Isern NG, Connell T, Wooten JB, Zedler BK, Dasika MS, Webb BT, Webb-Robertson BJ, Pounds JG, Murrelle EL, Leppert M, van den Oord EJCG: 1H Nuclear Magnetic Resonance Metabolomics Analysis Identifies Novel Urinary Biomarkers for Lung Function, J Proteome Res. 9(6):3083-90, 2010. PMID: 20408573

Conrad TM, Frazier M, Joyce AR, Cho BK, Knight EM, Lewis NE, Landick R, Palsson BØ. RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media. Proc Natl Acad Sci U S A. 107(47):20500-5, 2010. PMID: 21057108

Joyce AR, Hawkins W, Fariss MW, Sengupta TK. Role of plasma membrane disruption in reference moist smokeless tobacco-induced cell death. Toxicol Lett. 198(2):191-9, 2010 PMID: 20600711

Mitchell C, Joyce AR, Piper JT, McKallip RJ, Fariss MW. Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death. Toxicol Lett. 195(1):23-30, 2010. PMID: 20206247

Peterson RE, Maes HH, Holmans P, Sanders AR, Levinson DF, Shi J, Kendler KS, Gejman PV, Webb BT.Genetic risk sum score comprised of common polygenic variation is associated with body mass index. Hum Genet. [Epub ahead of print], 2010. PMID: 21104096

Thiselton DL, Maher B, Webb BT, Bigdeli TB, O’Neill FA, Walsh D, Kendler KS, Riley BP. Association analysis of the PIP4K2A gene on chromosome 10p12 and schizophrenia in the Irish Study of High Density Schizophrenia Families (ISHDSF) and the Irish Case-Control Study of Schizophrenia (ICCSS). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B(1):323-31, 2010.

Heitner SB, Hollenberg SM, Colilla SA. Heat maps, random forests, and nearest neighbors: a peek into the new molecular diagnostic world. Crit Care Med. 38(1):296-8, 2010. PMID: 20023468

Colilla SA. An epidemiologic review of smokeless tobacco health effects and harm reduction potential. Regul Toxicol Pharmacol. 56(2):197-211, 2010. PMID: 19796662

Åberg K, Adkins DE, Bukszár J, Webb BT, Carcoff S, Miller D, Perkins D, Sebat S, Stroup S, Vladimirov VI, McClay JL, Lieberman JA, Sullivan PF, van den Oord EJCG. Genome-wide association study of movement- related adverse drug effects in schizophrenic patients. Biological Psychiatry 2009 Oct 27.

Sun J, Jia P, Fanous A, Webb BT, van den Oord EJCG, Chen X, Bukszar J, Kendler KS, Zhao Z A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases – schizophrenia as a case. Bioinformatics, 25(19): 2595-6602, 2009.

Murrelle L, Coggins CR, Gennings C, Carchman RA, Carter WH Jr, Davies BD, Krauss MR, Lee PN, Schleef RR, Zedler BK, Heidbreder C: Hypotheses and fundamental study design characteristics for evaluating potential reduced-risk tobacco products. Part I: Heuristic. Regulatory Toxicology & Pharmacology 57:1-10, 2010.

Murrelle L, Gennings C, Carchman RA, Carter WH, Lee PN, Zedler BK, Coggins CRE, Heidbreder C: Further considerations on the evaluation of potential reduced-risk tobacco products. Part II: Re-assessment of a heuristic using the CPS-II database. Regulatory Toxicology & Pharmacology 57:11-17, 2010.

McCue C, Carchman RA, Zedler BK, McCue RJ. Family Smoking Prevention and Tobacco Control Act: Implications for the Law Enforcement Community. Food and Drug Law Institute Update Magazine Nov/Dec, 2009.

Conrad TM, Joyce AR, Applebee MK, Barrett CL, Xie B, Gao Y, Palsson BO. Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short- term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations. Genome Biol. 10(10):R118, 2009.

Mejia R, Torres de Galvis Y, Heidbreder C, Murrelle L. The Construct of Impulsivity within the Context of Gender-Specific Adversity and Resilience during Adolescence: Recommendations for Future Work. In Impulsivity: Causes, Control and Disorders, GH Lassitor (Editor), Nova Science, 2009.

Coggins CRE, Murrelle EL, Heidbreder C: Light and intermittent cigarette smokers: A review (1989-2009), Psychopharmacology (Online ISSN: 1432-2072), 2009.

Gianchandani EP, Joyce AR, Palsson BO, Papin JA. Functional States of the genome-scale Escherichia coli transcriptional regulatory system. PLoS Computational Biology, 5(6):e1000403, 2009.

Webb BT, McClay JL, York TP, Vargas-Irwin C, van den Oord EJCG. In Silico mapping of murine prepulse inhibition QTLs. PLoS One [Epub 2009 Apr 15], 2009.

Guo A, Webb BT, Miles MF, Zimmerman M, Kendler KS Zhao Z. ERGR: an ethanol-related gene resource. Nucleic Acids Research 37:D840-845 [Epub 2008 Oct], 2009.

Medland SE, Schmitt JE, Webb BT, Kuo PH, Neale MC. Efficient calculation of empirical p-values for genome wide linkage analysis through weighted permutation. Behavioral Genetics 39(1):91-100 [Epub 2008 Sep 23], 2009.

Joyce AR and Palsson BO. In silico Genome-scale Metabolic Models: The Constraint-based Approach and its Applications. in Systems Biology and Synthetic Biology. P. Fu, M. Latterich and S. Panke, Eds. John Wiley & Brothers, Inc.: Hoboken, NJ; 2009. pp. 193-233.

Zedler B, Frost-Pineda K, Oliveri D, Liang Q, Feng S, Roethig HJ. 12-Week clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers. Regul Tox Pharmacol. 52(2):111-117, 2008.

Eaves LJ, Prom EC, Hatemi PK, Murrelle EL. Family matters: Social influences exceed genetic effects on adolescent religious attitudes and practices. Social Forces 86(4):1621-1646, 2008.

Fanous AH, Neale MC, Webb BT, Straub RE, O’Neill FA, Walsh D, Riley BP, Kendler KS. Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high density families. Biological Psychiatry 64(2):121-127, 2008.

Frost-Pineda K, Zedler B, Oliveri D, Feng S, Liang Q, Roethig HJ. Short-term clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers. Regulatory Toxicology and Pharmacology 52(2):104-110, 2008.

Frost-Pineda K, Zedler B, Oliveri D, Liang Q, Feng S, Roethig HJ. 12-Week clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers. Regulatory Toxicology and Pharmacology 52(2):111-117, 2008.

Frost-Pineda K, Zedler BK, Liang Q, Roethig HJ. Environmental tobacco smoke (ETS) evaluation of a third-generation electrically heated cigarette smoking system (EHCSS). Regulatory Toxicology and Pharmacology 52(2):118-121, 2008.

Joyce AR and Palsson BO. Predicting gene essentiality using genome-scale in silico models. In: Osterman A and Gerdes S, editors. Gene essentiality at genome scale: protocols and bioinformatics. Totowa (NJ): Humana Press Inc.; 2008. pp. 433-457.

Meng H, Murrelle EL, Li G. Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles. BMC Bioinformatics 9:457-467, 2008.

Roethig HR, Feng S, Liang Q, Liu J, Rees WA, Zedler BK. A 12-month, randomized, controlled study to evaluate exposure and cardiovascular risk factors in adult smokers switching from conventional cigarettes to a second-generation electrically heated cigarette smoking system. Journal of Clinical Pharmacology 48(5):580-591, 2008.

Sullivan PF, Kuo P-H, Webb BT, Neale MC, Vittum J, Furberg H, Walsh D, Patterson DG, Riley B, Prescott CA, Kendler KS. Genomewide linkage survey of nicotine dependence phenotypes. Drug and Alcohol Dependence 93(3):210-216 [Epub 2007 Nov 19], 2008.

van den Oord EJCG, Po-Hsiu Kuo, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D. Genome-wide association analysis followed by a replication study implicates a novel neuroticism gene. Archives of General Psychiatry 65(9):1062-1071, 2008.

Webb BT, Sullivan PF, Tara Skelley, van den Oord EJCG. Model based gene selection shows EN1 is associated with antipsychotic response. Pharmacogenetics and Genomics 18(9):751-759, 2008.

Fanous AH, Neale MC, Webb BT, Riley BP, Gardner CO, Straub RE, O’Neill FA, Walsh D, Kendler KS. Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy. Molecular Psychiatry 12(10):958-965, 2007.

Fanous AH, Neale MC, Webb BT, Straub RE, Amdur R, O’Neill FA, Walsh D, Riley BP, Kendler KS. Genome-wide scan for modifier loci in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144(5):589-595, 2007.

Feist AM, Henry CS, Reed JL, Krummenacker M, Joyce AR, Karp PD, Broadbelt LJ, Hatzimanikatis V, Palsson BO. A genome-scale reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information. Molecular Systems Biology 3:121, 2007.

Hua Q, Joyce AR, Palsson BO, Fong SS. Metabolic characterization of Escherichia coli strains adapted to growth on lactate. Applied and Environmental Microbiology 73(14):4639-4647, 2007.

Joyce AR and Palsson BO. Toward whole cell modeling and simulation: comprehensive functional genomics through the constraint-based approach. In: Boshoff HI and Barry CE III, editors. Systems biological approaches in infectious diseases. Basel, Switzerland: Birkhauser Verlag; 2007. pp. 265, 267-309.

Kliewer W and Murrelle L. Risk and protective factors for adolescent substance use: Findings from a study of Central American youth. Journal of Adolescent Health 40:448-455, 2007.

Roethig HJ, Zedler BK, Kinser RD, Feng S, Nelson BL, Liang Q. Short-term clinical exposure evaluation of a second-generation electrically heated cigarette smoking system. Journal of Clinical Pharmacology 47(4):518-530, 2007.

Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NK, Arnold RC, Colilla S, Zanotti S, and Hollenberg SM. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Annals of Emerging Medicine 49(1):88-98, 2007.

Van den Oord EJC, McClay J, York T, Murrelle L, Robles JR. Genetics and diagnostic refinement. Behavior Genetics 37:535-545, 2007.

Webb BT, van den Oord EJCG, Akkari A, Wilton S, Barnes KC, Carlsen K, Gerritsen J, Helms P, Lenney W, Silverman M, Sly P, Sundy J, Tsanakas J, von Berg A, Whyte M, Blumenthal M, Vestbo J, Anderson WH, Pillai SG. Quantitative linkage genome scan for atopy in a large collection of Caucasian families. Human Genetics 121(1):83-92 [Epub 2006 Nov 14], 2007.

Allen TE, Price ND, Joyce AR, Palsson BO. Long-range periodic patterns in microbial genomes indicate significant multi-scale chromosomal organization. PLoS Computational Biology 2(1):e2, 2006.

Colilla S, Kantoff PW, Neuhausen SL, Godwin AK, Daly MB, Narod SA, Garber JE, Lynch HT, Brown M, Weber BL, Rebbeck TR. Modification of breast cancer risk by smoking and AIB1 in BRCA1 mutation carriers. Carcinogenesis 27(3):599-605, 2006.

Gianchandani EP, Papin JA, Price ND, Joyce AR, Palsson BO. Matrix formalism to describe functional states of transcriptional regulatory systems. PLoS Comput Biol 2(8):e101 (2006).

Herring CD, Raghunathan A, Honisch C, Patel T, Applebee MK, Joyce AR, Albert TJ, Blattner FR, van den Boom D, Cantor CR, Palsson BO. Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale. Nature Genetics 38(12):1406-1412, 2006.

Hua Q, Joyce AR, Fong SS, Palsson BO. Metabolic analysis of adaptive evolution for in silico-designed lactate-producing strains. Biotechnology and Bioengineering 95(5):992-1002, 2006.

Joyce AR and Palsson BO. The model organism as a system: integrating 'omics' data sets. Nature Reviews Molecular Cell Biology 7(3):198-210, 2006.

Joyce AR, Easterling K, Holtzman SG, Kuhar MJ. Modeling the onset of drug dependence: a consideration of the requirement for protein synthesis. Journal of Theoretical Biology 240(4):531-537, 2006.

Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S. Experimental and computational assessment of conditionally essential genes in Escherichia coli. Journal of Bacteriology 188(23):8259-8271, 2006.

Kendler KS, Kuo PH, Webb BT, Kalsi G, Neale MC, Sullivan PF, Walsh D, Patterson DG, Riley BP, Prescott CA. A Joint Genome wide linkage analysis of symptoms of alcohol dependence and conduct disorder. Alcoholism: Clinical and Experimental Research 30(12):1972-1977, 2006.

Kliewer W, Murrelle L, Prom E, Ramirez M, Obando P, Sandi L, Warner E, Karenkaris M del C. Violence exposure and drug use in central american youth:  family cohesion and parental monitoring as protective factors. Journal of Research on Adolescence 16:455-478, 2006.

Kuo PH, Neale MC, Riley BP, Webb BT, Sullivan PF, Vittum J, Patterson DG, Thiselton DL, van den Oord EJ, Walsh D, Kendler KS, Prescott CA. Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. Alcoholism: Clinical and Experimental Research 30(11):1807-1816, 2006.

McClay JL, Fanous A, van den Oord EJCG, Webb BT, Walsh D, O'Neill FA, Kendler KS, Chen X. Catechol-O-methyltransferase and the clinical features of psychosis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141(8):935-938, 2006.

Oh YK, Joyce AR, Palsson BO. Constraint-based genome-scale in silico models for systems biology. Asia-Pacific Biotech News 10:123-136, 2006.

Prescott CA, Sullivan PF, Kuo PH, Webb BT, Vittum J, Patterson DG, Thiselton DL, Myers JM, Devitt M, Halberstadt LJ, Robinson VP, Neale MC, van den Oord EJ, Walsh D, Riley BP, Kendler KS. Genome-wide linkage study in the Irish Affected Sib Pair Study of Alcohol Dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. Molecular Psychiatry 11(6):603-611, 2006.

Reed JL, Patel TR, Chen KH, Joyce AR, Applebee MK, Herring CD, Bui OT, Knight EM, Fong SS, Palsson BO. Systems approach to refining genome annotation. Proceedings of the National Academy of Sciences of the United States of America 103(46):17480-17484, 2006.

van den Oord EJCG, Rujescu D, Robles JR, Birrell C, Bukszár J, Murrelle L, Giegling I, Möller H-H-J, Middleton L, Muglia P. Factor structure and external validity of the PANSS revisited. Schizophrenia Research 82:213-223, 2006.

Zedler BK, Kinser R Oey J, Nelson B, Roethig HJ, Walk RA, Kuhl P, Rustemeier K, Schepers G, Von Holt K, Tricker AR. Biomarkers of exposure and potential harm in adult smokers of 3-7 mg tar yield (Federal Trade Commission) cigarettes and in adult non-smokers. Biomarkers 11(3):201-220, 2006.

Colilla S, Lerman C, Shields PG, Jepson C, Rukstalis M, Berlin J, DeMichele A, Bunin G, Strom BL, Rebbeck TR. Catechol-o-methyltransferase genotype and smoking cessation. Pharmacogenetics and Genomics 15(6):393-398, 2005.

Fong SS, Joyce AR, Palsson BO. Parallel adaptive evolution cultures of Escherichia coli lead to convergent growth phenotypes with different gene expression states. Genome Research 15(10):1365-1372, 2005.

Fong SS, Joyce AR, Palsson BO. The econometrics of evolution. Nature Chemical Biology 1(4):191-192, 2005.

Silberg JL, Febo San Miguel V, Murrelle EL, Prom E, Bates J, Canino G, Egger H, Eaves LJ. Genetic and environmental influences on temperament in the first year of life: The Puerto Rico Infant Twin Study (“PRINTS”). Twin Research 8:328-336, 2005.

Davanzo P, Kerwin L, Nikore V, Esparza C, Forness S, Murrelle L. Spanish translation and reliability testing of the child depression inventory. Child Psychiatry and Human Development 35:75-92, 2004.

Fanous A, Neale MC, Straub RE, Webb BT, Walsh D, O’Neill FA, Kendler KS. Clinical features of psychotic disorders and polymorphisms in serotonin 2A (HTR-2A), dopamine D2 (DRD2) and D4 (DRD4) receptors, dopamine transporter (DAT1), and brain-derived neurotrophic factor (BDNF) genes: a family-based association study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 125B(1):69-78, 2004.

Obando P, Kliewer W, Murrelle L, Svikis DS. The comorbidity of substance abuse and depressive symptoms in Costan Rican adolescents. Drug and Alcohol Dependence 76:37-44, 2004.

Thiselton DL, Webb BT, Neale B, Ribble RC, O’Neill FA, Walsh D, Riley BP, Kendler KS. No Evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish Study of High Density Schizophrenia Families (ISHDSF). Molecular Psychiatry 9(8):777-783, 2004.

Colilla S, Nicolae D, Pluznikov A, Blumenthal M, Beaty T, Meyers D, Lange E, Rich S, Bleecker E, Ober C, Cox N; Collaborative Study for the Genetics of Asthma. Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. Journal of Allergy and Clinical Immunology 111:840-846, 2003.

Kimmel HL and Joyce AR. Dopamine transporters: structure-activity relationships and regulation in neurons. In: Dopamine receptors and transporters, 2nd edition. Vernier P, Sidhi A, Laruelle M. editors. New York (NY): Marcel Dekker, Inc; 2003. pp. 467-500.

Kuhar MJ and Joyce AR. Is the onset of psychoactive drug effects compatible with a protein-synthesis mechanism? Neuropsychopharmacology 28 Suppl 1: S94-97, 2003.

Liu XZ, Ouyang XM, Xia XJ, Zheng J, Pandya A, Li F, Du LL, Welch KO, Petit C, Smith RJ, Webb BT, Yan D, Arnos KS, Corey D, Dallos P, Nance WE, Chen ZY. Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Human Molecular Genetics 12(10):1155-1162, 2003.

Naoumova RP, Bonney SA, Eichenbaum-Voline S, Patel HN, Jones B, Jones EL, Amey J, Colilla S, Neuwirth C, Allotey R, Seed M, Betteridge DJ, Galton DJ, Cox NJ, Bell GI, Scott J, Shoulders CC. Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia. Arteriosclerosis, Thrombosis, and Vascular Biology 23(11):2070-2077, 2003.

Anderson LS, Beverly WT, Corey LA, Murrelle L. The Mid-Atlantic Twin Registry. Twin Research 5:499-501, 2002.

Stern SJ, Arnos L, Murrelle L, Oelrich K, Nance W, Pandya A^. Attitudes of Deaf and Hard of Hearing Individuals toward Genetic Testing and Prenatal Diagnosis of Hearing Loss. Journal of Medical Genetics 39(6):449-453, 2002.

Strassberg M, Peters K, Marazita M, Ganger J, Watt-Morse M, Murrelle L, Tarter R, Vanyukov M. Pittsburgh Registry of Infant Multiplets (PRIM). Twin Research 5:499-501, 2002.

Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, Cesare AJ, Gibberman A, Wang X, O'Neill FA, Walsh D, Kendler KS. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of mouse dysbindin, is associated with schizophrenia. American Journal of Human Genetics 71(2):337-348, 2002.

Straub RE, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, O'Neill FA, Walsh D, Kendler KS. Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and followup of selected regions in all families provides evidence for multiple susceptibility genes. Molecular Psychiatry 7(6):542-559, 2002.

Colilla S, Cox, N, Erhmann D. Heritability of insulin secretion and insulin action in women with polycystic ovary syndrome and their first degree relatives. Journal of Clinical Endocrinology & Metabolism 86(5):2027-2031, 2001.

Colilla S, Tsalenko A, Pluzhnikov A, Cox N. Genome-wide approaches to identify interacting susceptibility regions. Genetic Epidemiology 21(Suppl 1):S266-271, 2001.

Hollenberg SM, Dumasius A, Easington C, Colilla SA, Neumann A, Parrillo JE. Characterization of a hyperdynamic murine model of resuscitated sepsis using echocardiography. American Journal of Respiratory and Critical Care Medicine 164(5):891-895, 2001.

Kimmel HL, Joyce AR, Carroll FI, Kuhar MJ. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. The Journal of Pharmacology and Experimental Therapeutics 298(1): 129-140, 2001.

Kliewer W, Murrelle L, Mejia R, Torres de Y, Angold A. Exposure to violence against a family member and internalizing symptoms in Colombian adolescents: the protective effects of family support. Journal of Consulting and Clinical Psychology 69(6):971-982, 2001.

Kuhar MJ and Joyce AR. Slow onset of CNS drugs: can changes in protein concentration account for the delay? Trends in Pharmacological Sciences 22(9):450-456, 2001.

Kuhar MJ, Joyce A, Dominguez G. Genes in drug abuse. Drug and Alcohol Dependence 62(3):157-162 2001.

Liu XZ, Blanton SH, Bitner-Glindzicz M, Pandya A, Landa B, MacArdle B, Rajput K, Bellman S, Webb BT, Ping X, Smith RJ, Nance WE. Haplotype analysis of the USH1D locus and genotype-phenotype correlations. Clinical Genetics 60(1):58-62, 2001.

Murrelle L and McCarthy C. What’s so important about conducting research involving third parties. Journal of Continuing Education in the Health Professions 21(4):198-202, 2001.

Sullivan PF, Neale MC, Silverman MA, Harris-Kerr C, Myakishev MV, Wormley B, Webb BT, Ma Y, Kendler KS, Straub RE. An association study of DRD5 with smoking initiation and progression to nicotine dependence. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 105 (3): 259-265, 2001.

Vrana PB, Matteson PG, Schmidt JV, Ingram RS, Joyce A, Prince KL, Dewey MJ, Tilghman SM. Genomic imprinting of a placental lactogen gene in Peromyscus. Development Genes and Evolution 211(11):523-532, 2001.

Colilla S, Rotimi C, Cooper R, Goldberg J, Cox N. The genetic inheritance of body mass index in African-American and African families. Genetic Epidemiology 18(4):360-376, 2000.

Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schultze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell G. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nature Genetics 26(2):163-175, 2000.

Maya J, Torres de G. Y, Murrelle L, Mejía R, Calderón G. Consumption of psychoactive substances and other factors associated with juvenile delinquency. Monograph of the Institute for Health Sciences (CES), Medellín, Colombia, 2000.

D’Onofrio B, Eaves L, Murrelle L, Maes H, Spilka B. Understanding biological and social influences on religious attitudes and behaviors: A behavior-genetic perspective. Journal of Personality 67:953-984, 1999.

D’Onofrio BM, Murrelle L, Eaves LJ, McCullough ME, Landis JL, Maes HH: Adolescent religiousness and its influence on alcohol and drug use: Preliminary findings from the Mid-Atlantic Twin Study. Twin Research 60:293-305, 1999.

Gann PH, Colilla SA, Gapstur SM, Winchester DJ, Winchester DP. Factors associated with axillary node metastasis from breast carcinoma: descriptive and predictive analysis. Cancer 86(8):1511-1519, 1999.

Maes HH, Woodard CE, Murrelle L, Meyer JM, Silberg JL, Hewitt JK, Rutter M, Simonoff E, Pickles A, Neale MC, Eaves LJ. Tobacco, alcohol and drug use in 8-16 year old twins: The Virginia Twin Study of Adolescent Behavioral Development (VTSABD). Journal of Studies on Alcohol 60:293-305, 1999.

Pineda DA, Henao GC, Puerta IC, Mejia SE, Gomez LF, Miranda ML, Rosselli M, Ardila A, Restrepo MA, Murrelle L. The use of brief questionnaire in the diagnosis of attention deficit. Reviews in Neurology 28(4):365-372, 1999.

Silberg JL, Pickles A, Rutter ML, Siminoff E, Hewitt JK, Maes HK, Carbonneau R, Murrelle L, Foley D, Eaves L. The influence of genetic factors and life stress on depression among adolescent girls. Archives of General Psychiatry 56:225-232, 1999.

Straub RE, Sullivan PF, Ma Y, Myakishev MV, Harris-Kerr C, Wormley B, Kadambi B, Sadek H, Silverman MA, Webb BT, Neale MC, Bulik CM, Joyce PR, Kendler KS. Susceptibility genes for nicotine dependence: a genome scan and follow up in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Molecular Psychiatry 4(2):129-144, 1999.

Breembroek GRM, van Straalen A, Witkamp GJ, van Rosmalen GM, Moss HB, Bonicatto S, Kirisci L, Giradelli AM, Murrelle L. Substance abuse and associated psychosocial problems among argentine adolescents in Buenos Aires Province: Sex heterogeneity and familial transmission. Drug and Alcohol Dependence 52:221-230, 1998.

Majumder PP, Moss HB, Murrelle L. Familial and non-familial factors in the prediction of disruptive behaviors in boys at risk for substance abuse. Journal of Child Psychology and Psychiatry 39:203-213, 1998.

Straub RE, MacLean CJ, Martin RB, Ma Y, Myakishev MV, Harris-Kerr C, Webb BT, O'Neill FA, Walsh D, Kendler KS. A schizophrenia locus may be located in region 10p15-p11. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 81(4):296-301, 1998.

Brigham J, Moss HB, Murrelle L, Herning RI, Tarter RE. Event-related potential negative shift in sons of polysubstance- and alcohol-use disorder fathers. Psychiatry Research 73:133-146, 1997.

Gapstur SM, Dupuis J, Gann P, Colilla S, Winchester DP. Hormone receptor status of breast tumors in black, Hispanic and non-Hispanic white women: An analysis of 13,239 cases. Cancer 77:1465-1471, 1996.

Kendler KS, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Easter SM, Webb BT, Zhang J, Walsh D, Straub RE. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. American Journal of Psychiatry 153(12):1534-1540, 1996.

Straub RE, MacLean CJ, O’Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Webb BT, Zhang J, Walsh D, Kendler KS. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nature Genetics 11(3):287-293, 1995.

Correll PH, Colilla S, Karlsson S. Retroviral design for long-term expression in murine hematopoietic cells in vivo. Blood 84(6):1812-1822, 1994.

Correll PH, Colilla S, Brady RO, Karlsson S. Expression of the glucocerebrosidase gene following transfer into primitive hematopoietic cells of mice. In: Molecular biology of hematopoiesis. Abraham NG, Marks P, Levine AS, Konwalinka G, editors. Intercept Ltd: Andover, England; 1993.

Overstreet DH, Kampov-Polevoy A, Rezvani AH, Murrelle L, Halikas JA, Janowsky DS. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcoholism: Clinical and Experimental Research 17:1-4, 1993.

Correll PH, Colilla S, Dave HG, Brady RO, Karlsson S. Gene therapy of inherited disorders with special reference to Gaucher disease. In: Correction of genetic disorders by transplantation. Hobbs JR, editor. London, England; 1992.

Correll PH, Colilla S, Dave HPG, Karlsson S. High levels of human glucocerebrosidase activity in macrophages of long-term reconstituted mice following retroviral infection of hematopoietic stem cells. Blood 80(2):331-336, 1992.

Murrelle L, Ainsworth BE, Doody JM, Holliman SC, Bulger D. Computerized mental health screening for college students: Correlation with standard pencil and paper questionnaires. American Journal of Health Promotion 7:90-92, 1992.

Montoya ID, Murrelle L. Prevalence of clinical depression as measured by the Zung Self-Rating Depression Scale (SDS) in physicians during post-graduate medical training in Medellín, Colombia. Medicina Universidad Pontificia Bolivariana 8(1):59-72, 1989 [Spanish].

Murrelle L, Escalona R, Florenzano R. Epidemiologic report on psychoactive substance use in 16 countries of Latin American and the Caribbean. Bulletin of the Panamerican Health Organization 107(6):595-644, 1989.

Murrelle L, Torres de Galvis Y, Orejuela E. Diagnostic tests as a clinical aid and for use in mental health screening. In: Application, Scoring and Interpretation Manual for the Second National Workshop on the Use of Clinical-Research Instruments in Addiction, Mental Hospital of Antioquia, Medellín, Colombia; pp. 110-115, 1988.

Murrelle L. Alcoholism research: A new approach to an old problem. Source 2(1):23-26, 1989.

Murrelle L. Alcoholism: Genetic and biochemical aspects. Revista del Hospital Mental de Antioquia 12(3): 13-18, 1986 [Spanish].

Murrelle L. PC Statistician: A “friendly” biostatistics package for the microcomputer. In: Application, scoring and interpretation manual for the second national workshop on the use of clinical-research instruments in addiction. Mental Hospital of Antioquia: Medellín, Colombia; 1988. pp. 127-131.

Torres de Galvis Y, Murrelle L. National household survey on alcoholism and the consumption of dependence-producing substances, Colombia - 1987. University of Antioquia Press: Medellín, Colombia; 1988.

Torres de Galvis Y, Murrelle L. The consumption of dependence-producing substances in Colombia. Bulletin of the Panamerican Health Organization 107(6):485-494, 1989.

Edenberg HJ, Daniel L. Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI, Rice JP, Schuckit MA, Taylor R, Webb BT, Tischfield JA, Porjesz B, Foroud T. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcoholism, Clinical and Experimental Research Dec 2009 (in press).

Hatemi PK, Gillespie NA, Eaves LJ, Maher BS, Medland SE, Smyth DC, Beeby HN, Gordon SC, Montgomery GW, Zhu G, Byrne E, Webb BT, Heath AC, Martin NG. Results from the First Genome-wide Linkage of Liberal and Conservative Political Attitudes. Journal of Politics Dec 2009 (in press).

Maher BS, Vladimirov VI, Latendresse SJ, Thiselton DL, McNamee R, Kang M, Bigdeli TB, Chen X, Riley BP, Hettema JM, Chilcoat H, Heidbreder C, Muglia P, Murrelle EL, Dick DM, Aliev F, Devlin B, Ferrell RE, Kirillova GP, Tarter RE, Kendler KS, Vanyukov MM: The AVPR1A gene and Substance Use Disorders: Association, Replication and Functional Evidence, Biological Psychiatry, 2010.

Basu P, Edmiston J, Li Guoya, Murrelle L, Sengupta TK: Changes in DNA Methylation of cox-2 and Other Key Genes by Cigarette Smoke Condensate (TPM) in an in vitro System of Human Micro Endothelial Cells, Under Review, Epigenetics, 2010.